Clinical Resources
NovoSorb® BTM (Biodegradable Temporising Matrix) is a unique synthetic dermal scaffold that provides an effective reconstructive option for a range of complex wounds.1,2
NovoSorb® BTM is composed of wound-facing biodegradable foam bonded to a non-biodegradable transparent sealing membrane. Developed for the treatment of full-thickness wounds where the dermal structure has been lost to trauma or surgical debridement.
“The synthetic composition means that it is not prone to attack by microorganisms (it is not a ‘foodstuff’). Thus, infection is uncommon and, if it does occur, is localised and manageable without loss of the matrix.” 1,3
Professor John Greenwood, Royal Adelaide Hospital
Sealing membrane
Physiologically closes the wound, minimising moisture loss from the wound, minimising contraction and forming a mechanical barrier to infection.1,7,8
Synthetic material
NovoSorb® BTM is a biodegradable device designed to facilitate the dermis to grow within a polyurethane matrix.2
Open cell matrix
Angiogenesis through the interconnected chambers provide a vascular network throughout the matrix that can deliver immune cells to fight infection in the wound bed.9
Clinical Case Studies
Robust in the presence of infection10,11
Does not act as a food source for infections, often allowing retention while the infection is treated.
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Pre-operative
Week 2
Week 3
Week 4.5
4 months
Designed to minimise contracture over functionally important areas and improve cosmesis (uniformity of texture)12
Compared with primary skin grafting.
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Post debridement
Integrated
3 months
Generation of a neodermis over exposed tendons and bones11,12,13
Can offer alternative treatment for complex wounds.
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Pre-operative
Integrating
4 months
Dermal repair to support limb salvage14
By creating a vascularised neodermis for definitive closure.
Read case study
Pre-operative
Application
3 months
Clinical Education
We have a number of educational resources to help you gain a greater understanding of NovoSorb® BTM and its benefits to your patients:
Clinical webinars
This series of clinical webinars are presented by leading surgeons from around the globe. Featuring clinical study outcomes and case reports, as well as their recommended approach and tips, for a range of cases from upper extremity trauma to soft tissue infection and chronic wounds.
Follow the link below to register for insights from your peers.
Case Studies
A broad range of patient case reports that demonstrate the clinical outcomes, versatility and breadth of applications for NovoSorb® BTM.
NovoSorb® BTM is indicated for full or deep partial thickness burns and wounds, surgical and reconstructive wounds and traumatic wounds.
Clinical publications
Surgeons from multiple different specialties have used BTM to evaluate efficacy and outcomes. They have shared their experience as the use of BTM has expanded and often share their surgical protocols so that other surgeons can learn about their approach, recommendations, challenges
Click below for a comprehensive list of peer-reviewed publications.
References
- Greenwood JE, Schmitt BJ, Wagstaff MJD. Experience with a synthetic bilayer Biodegradable Temporising Matrix in significant burn injury. Burns Open. 2018; 2(1):17–34.
- Solanki NS, York B, Gao Y, Baker P, Wong She RB. A consecutive case series of defects reconstructed using NovoSorb® Biodegradable Temporising Matrix: Initial experience and early results. Journal of Plastic, Reconstructive & Aesthetic Surgery. 2020; 73(10):1845–53.
- Greenwood JE. A paradigm shift in practice—the benefits of early active wound temporisation rather than early skin grafting after burn eschar excision. Anaesthesia and Intensive Care. 2020; Epub Apr 1.
- Wagstaff MJD, Schmitt BJ, Caplash Y, et al. Free flap donor site reconstruction: A prospective case series using an optimized polyurethane temporizing matrix. ePlasty 2015; 15: 231–248.
- Wagstaff MJD, Salna I, Caplash Y, et al. Use of a biodegradable synthetic dermal matrix in the reconstruction of defects after serial debridement for necrotising fasciitis: A case series. Burns Open 2018; 3: 12–30.
- Damkat-Thomas L, Greenwood JE and Wagstaff MJD. A synthetic Biodegradable Temporising Matrix in degloving lower extremity trauma reconstruction: A case report. Plast Reconstr Surg Global Open 2019; 7: e2110.
- Wagstaff MJD, Schmitt B, Caplash Y, Greenwood JE. Free flap donor site reconstruction: A prospective case series using an optimized polyurethane temporizing matrix. Eplasty. 2015; 15:231–48.
- Dearman B, Greenwood J. A Composite Cultured Skin- Bench to Bedside. Presented at 43rd Annual Scientific Meeting of the Australian and New Zealand Burn Association (ANZBA). 15–18 Oct 2019. Hobart, Australia.
- Greenwood JE, Wagstaff MJD. The use of biodegradable polyurethane in the development of dermal scaffolds. Chapter 22. S.L. Cooper, J. Guan (Eds.), Advances in Polyurethane Biomaterials, Woodhead Publishing Series in Biomaterials, (Elsevier Inc.), Duxford, UK (2016).
- Greenwood JE, Dearman BL. Comparison of a sealed, polymer foam biodegradable temporizing matrix against Integra® dermal regeneration template in a porcine wound model. J Burn Care Res. 2012; 33:163-73.
- Greenwood JE, Schmitt BJ, Wagstaff MJD. Experience with a synthetic bilayer Biodegradable Temporising Matrix in significant burn injury. Burns Open. 2018;2(1):17-34.
- Wagstaff MJD, Salna IM, Caplash Y, Greenwood JE. Biodegradable Temporising Matrix (BTM) for the reconstruction of defects following serial debridement for necrotising fasciitis: A case series. Burns Open. 2019; 3:12–30.
- Wagstaff MJD, Schmitt BJ, Coghlan P, Finkemeyer JP, Caplash Y, Greenwood JE. A biodegradable polyurethane dermal matrix in reconstruction of free flap donor sites: a pilot study. ePlasty 2015; 15:102–18.
- Data on file.